ES2046196T3 - Derivados de azacicloalcanos, promotores de absorcion que contienen los derivados como ingrediente eficaz y preparaciones externas que contienen los promotores de absorcion. - Google Patents

Derivados de azacicloalcanos, promotores de absorcion que contienen los derivados como ingrediente eficaz y preparaciones externas que contienen los promotores de absorcion.

Info

Publication number
ES2046196T3
ES2046196T3 ES198787200183T ES87200183T ES2046196T3 ES 2046196 T3 ES2046196 T3 ES 2046196T3 ES 198787200183 T ES198787200183 T ES 198787200183T ES 87200183 T ES87200183 T ES 87200183T ES 2046196 T3 ES2046196 T3 ES 2046196T3
Authority
ES
Spain
Prior art keywords
derivatives
absorption promoters
absorption
effective ingredient
azacicloalcanos
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787200183T
Other languages
English (en)
Spanish (es)
Inventor
Masayoshi Tsuji
Hisataka Inoue
Terumi Hachiya
Mikio Nakashima
Masaru Saita
Yuji Shimozono
Akira Nakagawa
Michinori Sakai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hisamitsu Pharmaceutical Co Inc
Original Assignee
Hisamitsu Pharmaceutical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co Inc filed Critical Hisamitsu Pharmaceutical Co Inc
Application granted granted Critical
Publication of ES2046196T3 publication Critical patent/ES2046196T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24Oxygen or sulfur atoms
    • C07D207/262-Pyrrolidones
    • C07D207/2632-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/2672-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24Oxygen or sulfur atoms
    • C07D207/262-Pyrrolidones
    • C07D207/2632-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/272-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74Oxygen atoms
    • C07D211/76Oxygen atoms attached in position 2 or 6
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08Oxygen atoms
    • C07D223/10Oxygen atoms attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/301,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/321,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D279/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/101,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/121,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D281/00Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02Seven-membered rings
    • C07D281/04Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/06Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
ES198787200183T 1986-04-08 1987-02-07 Derivados de azacicloalcanos, promotores de absorcion que contienen los derivados como ingrediente eficaz y preparaciones externas que contienen los promotores de absorcion. Expired - Lifetime ES2046196T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61079174A JPH0643390B2 (ja) 1986-04-08 1986-04-08 アザシクロアルカン誘導体

Publications (1)

Publication Number Publication Date
ES2046196T3 true ES2046196T3 (es) 1994-02-01

Family

ID=13682615

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787200183T Expired - Lifetime ES2046196T3 (es) 1986-04-08 1987-02-07 Derivados de azacicloalcanos, promotores de absorcion que contienen los derivados como ingrediente eficaz y preparaciones externas que contienen los promotores de absorcion.

Country Status (14)

Country Link
US (1) US4882359A (en])
EP (1) EP0241050B1 (en])
JP (1) JPH0643390B2 (en])
KR (1) KR910000164B1 (en])
CN (2) CN1020605C (en])
AR (1) AR245107A1 (en])
AT (1) ATE81505T1 (en])
AU (1) AU601402B2 (en])
CA (1) CA1336597C (en])
DE (1) DE3782182T2 (en])
ES (1) ES2046196T3 (en])
GR (1) GR3006768T3 (en])
SU (3) SU1748644A3 (en])
WO (1) WO1987006226A2 (en])

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3779833T2 (de) * 1986-01-31 1993-02-04 Whitby Research Inc Zusammensetzungen enthaltend 1-substituierte azacycloalkane und deren verwendung.
US5472946A (en) * 1988-04-08 1995-12-05 Peck; James V. Transdermal penetration enhancers
CA1334646C (en) * 1988-04-08 1995-03-07 James Vanolden Peck Transdermal penetration enhancers
US5234959A (en) * 1988-04-08 1993-08-10 Whitby Research, Inc. Penetration enhancers for transdermal delivery of systemic agents
US5041435A (en) * 1988-08-13 1991-08-20 Santen Pharmaceutical Co., Ltd. Cyclic sulfur-containing compounds
ES2063369T3 (es) * 1989-08-03 1995-01-01 Hisamitsu Pharmaceutical Co Crema para la piel, para uso externo.
IL91928A (en) * 1989-10-08 1994-07-31 Amrad Res & Dev Pharmaceutical compositions containing prolactin
US5070084A (en) * 1990-02-26 1991-12-03 Campbell James N Treatment of sympathetically maintained pain
US6559186B1 (en) 1990-02-26 2003-05-06 Arc 1, Inc. Compositions and methods of treatment of sympathetically maintained pain
FR2663932B1 (fr) * 1990-06-29 1994-04-29 Cird Galderma N-alkyl oxo-1 et dioxo-1,1 thiamorpholinones-3 et leurs utilisations comme agents de penetration de composes actifs dans des compositions therapeutiques et cosmetiques.
JPH078806B2 (ja) * 1990-08-16 1995-02-01 旭化成工業株式会社 カルシトニン類含有経鼻投与用乳剤
FR2666962B1 (fr) * 1990-09-26 1996-06-14 Oreal Composition antifongique sous forme de spray sec.
US5158763A (en) * 1990-10-09 1992-10-27 Colgate-Palmolive Company Non-staining anti-bacterial oral composition
JPH07595B2 (ja) * 1990-10-31 1995-01-11 久光製薬株式会社 アザシクロアルカン誘導体の製造方法
US5206386A (en) * 1991-03-20 1993-04-27 Isp Investments Inc. Controlled release N-substituted pyrrolidone esters and process for the use thereof
JP3090353B2 (ja) * 1991-09-17 2000-09-18 旭化成工業株式会社 パラチロイドホルモン類含有経鼻投与用乳剤
EP0608433B1 (en) * 1992-07-13 2004-05-19 Shiseido Company, Ltd. Composition for dermatologic preparation
WO1995011042A1 (fr) * 1993-10-21 1995-04-27 Hisamitsu Pharmaceutical Co., Inc. Composition administree par voie nasale et preparation contenant celle-ci
DE4337945A1 (de) * 1993-11-06 1995-05-11 Labtec Gmbh Pflaster zur Behandlung von Nagelmykosen
GB9325854D0 (en) * 1993-12-17 1994-02-23 Smithkline Beecham Corp Porcess
US6262117B1 (en) 1999-02-18 2001-07-17 Allergan Sales, Inc. Method and composition for treating acne
JP2000247911A (ja) 1999-02-26 2000-09-12 Hisamitsu Pharmaceut Co Inc 大腸用吸収促進剤
JP4653282B2 (ja) * 2000-05-23 2011-03-16 昭和薬品化工株式会社 ミノサイクリン含有組成物
RU2311409C2 (ru) * 2003-01-10 2007-11-27 Ф.Хоффманн-Ля Рош Аг Производные 2-пиперидона в качестве агонистов простагландина
JP4504210B2 (ja) * 2005-01-25 2010-07-14 花王株式会社 染毛剤組成物
US8026266B2 (en) 2005-11-08 2011-09-27 Arcion Therapeutics, Inc. Treatment of length dependent neuropathy
CN118141709B (zh) * 2024-02-22 2025-04-22 北京逆之龄生物科技有限公司 一种抗衰老化妆品及其制备方法和应用

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DE871154C (de) * 1942-08-26 1953-03-19 Basf Ag Verfahren zur Herstellung oberflaechenwirksamer Verbindungen
GB947910A (en) * 1960-11-04 1964-01-29 Gen Aniline & Film Corp Surface active ethers of n-(hydroxymethyl)-lactams
US3188317A (en) * 1961-12-22 1965-06-08 Dow Chemical Co Oxazolidinone derivatives
US3228955A (en) * 1962-01-18 1966-01-11 Dow Chemical Co Certain substituted oxazolidinones and pyrrolidinones
DE1177641B (de) * 1962-06-12 1964-09-10 Kalk Chemische Fabrik Gmbh Verfahren zur Herstellung von N-(ª‰-Hydroxy-alkyl)-oxazolidonen-(4) bzw. deren Polyaether
DE1241830B (de) * 1962-11-02 1967-06-08 Kalk Chemische Fabrik Gmbh Verfahren zur Herstellung von AEthern des N-Methylol-2, 2, 5, 5-tetramethyloxazolidons-(4)
US3232952A (en) * 1963-09-20 1966-02-01 Kalk Chemische Fabrik Gmbh Di-(oxazolidinone-(4)-n-alkyl)-ethers
DE1695846A1 (de) * 1967-05-05 1971-05-13 Schwarzkopf Gmbh Hans Verfahren zur Darstellung von Thioaethern mit reduktiven Eigenschaften
DE2114295A1 (de) * 1970-03-27 1971-10-14 Gaf Corp Substituierte AEtherderivate des N-Hydroxymethyl-2-pyrrolidinon und Verfahren zu deren Herstellung
DE2114251A1 (de) * 1970-03-30 1971-10-14 Gaf Corp Tertiaere Aminomethylderivate des N-Hydroxymethyl-2-pyrrolidinon und Verfahren zu deren Herstellung
US3956313A (en) * 1970-04-13 1976-05-11 Gaf Corporation N-(substituted-thiomethyl)-2-pyrrolidinones
US3991203A (en) * 1975-06-19 1976-11-09 Nelson Research & Development Company Vehicle composition containing 1-substituted azacyclopentan-2-ones
US4415563A (en) * 1980-04-04 1983-11-15 Nelson Research & Development Company Vehicle composition containing 1-substituted azacyclononan-2-ones
US4424210A (en) * 1980-04-04 1984-01-03 Nelson Research & Development Company Vehicle composition containing 1-substituted azacycloalkan-2-ones
US4444762A (en) * 1980-04-04 1984-04-24 Nelson Research & Development Company Vehicle composition containing 1-substituted azacyclopentan-2-ones
US4423040A (en) * 1980-04-04 1983-12-27 Nelson Research & Development Company Vehicle composition containing 1-substituted azacyclohexan-2-ones
FR2525106B1 (fr) * 1982-04-15 1985-06-07 Oreal Composition cosmetique contenant en tant qu'agent actif sur l'elasticite et la souplesse de la peau, de la thiamorpholinone ou l'un de ses derives
FR2525220A1 (fr) * 1982-04-15 1983-10-21 Oreal Nouveaux derives substitues de la thiamorpholinone et leurs procedes de preparation
US4450102A (en) * 1982-11-02 1984-05-22 Phillips Petroleum Company Sulfur based metal cleaners and corrosion inhibitors

Also Published As

Publication number Publication date
EP0241050B1 (en) 1992-10-14
JPS62238261A (ja) 1987-10-19
AR245107A1 (es) 1993-12-30
US4882359A (en) 1989-11-21
CN1018452B (zh) 1992-09-30
DE3782182D1 (de) 1992-11-19
EP0241050A3 (en) 1988-12-28
KR880701227A (ko) 1988-07-26
SU1748644A3 (ru) 1992-07-15
WO1987006226A3 (en) 1988-04-07
AU601402B2 (en) 1990-09-13
SU1750422A3 (ru) 1992-07-23
AU7020787A (en) 1987-11-09
GR3006768T3 (en]) 1993-06-30
JPH0643390B2 (ja) 1994-06-08
DE3782182T2 (de) 1993-02-25
EP0241050A2 (en) 1987-10-14
CN1060287A (zh) 1992-04-15
CN1020605C (zh) 1993-05-12
CA1336597C (en) 1995-08-08
KR910000164B1 (ko) 1991-01-21
ATE81505T1 (de) 1992-10-15
CN87100666A (zh) 1987-10-21
WO1987006226A2 (en) 1987-10-22
SU1750423A3 (ru) 1992-07-23

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